In further reading the user manual, Chapter 5 specifically, I am realizing how important this topic will be - for me at least. Page 250 of the manual states, "Without the use of the Document Orientation, it would not be possible to use Instant Developer's synchronization framework."
So if I plan to have an application that works on both browsers and mobile devices, which is the reason I am looking to use In.de, then I must be sure that my database is setup correctly to leverage the DO and it's synchronization features.